Levels of transferrin saturation and ferritin in selected genotypes over a follow-up period of up to 25 years, shown as a function of follow-up time. Twenty-three C282Y homozygotes were each matched for sex, age, and alcohol consumption with 2 persons each of wild type/wild type and C282Y/H63D genotypes. Data for a given individual are connected with lines. Panels to the right show local linear regression curves for women and men separately.