Increased transcription of inflammatory mRNA on day 20 in tc-ptp^-/- animals. The mRNA levels for (A) TNF-α, (B) iNOS, and (C) IFN-γ in tc-ptp^-/- mice (▪) and their wild-type littermates (□) at 20 days after birth. Bars represent the mean ± SE from 4 to 5 mice with tc-ptp^-/- values shown as fold increase from those of age-matched tc-ptp^+/+ mice. Statistical significance was determined by a 2-tailed unpaired Student t test. ^*P < .05; ^**P < .005; ^***P < .001 tc-ptp^-/- compared with tc-ptp^+/+.