Maximum serum Epo concentration for each Dox induction cycle. (A) Dox-induced Epo secretion measured at the peak level in the serum of Mac 9 through Mac 17 after rAAV-2-mediated (red), rAAV-1-mediated (black), and rAAV-5-mediated (blue) gene transfer. Each induction (referred to as “Induction peaks ”) lasted 5 days and was repeated every month for 5 months. (B) Amounts of rAAV-2 (red), rAAV-1 (black), and rAAV-5 (blue) vector administered expressed as vector genome/kg determined by dot blot. Mean Epo levels before vector injection are represented by error bars.