Pleiotropic RBC morphologies in F2 wan homozygotes. (A) Wright-stained peripheral blood smear showing extreme microspherocytosis and tubular membrane extensions (arrow). Note that some microcytes (arrowheads) are smaller than platelets (asterisks). (B) Peripheral blood smear showing significantly improved overall RBC morphology. Evidence of some membrane loss, however, persists (arrows). Bar = 10 μM.