Inactivation of FGFR3 induces differentiation of KMS11 cells in vivo.KMS11-derived tumors from placebo- and PD173074-treated mice analyzed by hematoxylin and eosin (H&E) staining and immunostaining for CD31, Ki-67, and cleaved caspase 3. No effect of PD17074 treatment was noted in 8226 tumors similarly treated (data not shown). Original magnification, × 400.