The mean ratio of IL-2 cycles per patient over time. This is shown in 6-month intervals according to the number of IL-2 cycles for all participants (solid gray line) and for each individual study: sc IL-2 (dashed line, •), sc 500 (dashed line, ▪), and msc IL-2 (dashed line, ▵). The number of evaluable patients at each time point is indicated.