ICSBP and bcl-2 expression in healthy donors and patients with CML. The expression levels of ICSBP and bcl-2 of each healthy donor or patient with CML was quantitated from peripheral blood cDNA by quantitative PCR and is outlined in the percentage of normalized to GAPDH. ICSBP and bcl-2 transcript levels are depicted by black (ICSBP) or open (bcl-2) symbols. Sample-specific expression pairs are indicated by connecting lines. NB (healthy donors, n = 7), CML-CP (chronic phase CML, untreated, n = 10), IFNα mcR (major cytogenetic responders with < 35% Ph-positive cells in bone marrow, n = 10).