Cumulative incidence of bone marrow failure (BMF), leukemia (AML), and solid tumor (ST), by age. Shaded regions show 95% pointwise confidence limits. CABS indicates congenital abnormality score and includes 1 point each for abnormalities in the set: developmental delay, heart or lung, kidney, hearing, and head. RAD indicates abnormal radii. The RAD = 0, CABS = 0 group (A) is at relatively low risk of BMF compared with other FA risk groups. The RAD = 1, CABS = 5 group (D) is at high risk of BMF, and the RAD = 1, CABS = 0 and RAD = 0, CABS = 5 groups (B and C, respectively) are at intermediate risk of BMF.