Figure 1.
Figure 1. Secondary structures of a maxizyme targeting the p190-type bcr-abl fusion gene. The e1a2Mz forms active and inactive structures when it recognizes and binds to p190-type bcr-abl mRNA (A) and normal c-abl mRNA (B), respectively.16 The gray shaded areas represent the squence of c-abl mRNA, and the bold letters “CUC” are the NUX sequence. *Non-Watson-Crick base pair.

Secondary structures of a maxizyme targeting the p190-type bcr-abl fusion gene. The e1a2Mz forms active and inactive structures when it recognizes and binds to p190-type bcr-abl mRNA (A) and normal c-abl mRNA (B), respectively.16  The gray shaded areas represent the squence of c-abl mRNA, and the bold letters “CUC” are the NUX sequence. *Non-Watson-Crick base pair.

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