HPC mobilization by G-CSF in DPP-I–deficient mice treated with a broad-spectrum metalloproteinase inhibitor. DPP-I–deficient mice (n = 3, each) were treated with 30 mg/kg MMI270 or vehicle alone (control) by continuous subcutaneous infusion for 6 days. On days 2 to 6, mice received 250 μg/kg G-CSF per day for 5 days, and the number of CFU-Cs in the bone marrow, blood, and spleen was quantified 4 hours after the final dose of G-CSF. Data represent the mean ± SD.