Effects of anti-P-selectin and anti-E-selectin mAbs on subacute (4-hour) Ang II-induced leukocyte responses within rat mesenteric arterioles. Rats were treated intraperitoneally with saline (n = 6) or 1 nM Ang II (n = 6). In further groups of animals, 15 minutes before intraperitoneal administration of 1 nM Ang II, rats were treated with anti-P-selectin mAb (n = 5), anti-E-selectin mAb (n = 5), or a combination of both (n = 4). Four hours later, arteriolar leukocyte adhesion responses were quantified. Results are represented as mean ± SEM. ^*P < .05 relative to the saline group. +P < .05 relative to the 1 nM Ang II group.