Effects of anti-α4-integrin, anti-VCAM-1, anti-β2-integrin, and anti-ICAM-1 mAbs on subacute (4-hour) Ang II-induced leukocyte responses within rat mesenteric postcapillary venules. Rats were treated intraperitoneally with saline (n = 6) or 1 nM Ang II (n = 6). In other groups of animals, 15 minutes before intraperitoneal administration of 1 nM Ang II, rats were treated with anti-α4-integrin mAb (n = 5), anti-VCAM-1 mAb (n = 4), anti-β2-integrin mAb (n = 5), or anti-ICAM-1 mAb (n = 5). Four hours later, responses were quantified for leukocyte rolling flux (A), leukocyte rolling velocity (B), leukocyte adhesion (C), and leukocyte emigration (D). Results are represented as mean ± SEM. **P < .01 relative to the saline group. +P < .05 and ++P < .01 relative to the 1 nM Ang II group.
