Figure 3.
Figure 3. No relationship between the epitope-specific cytotoxic activity of HIV-1-specific CD8+ T cells and their maturation phenotype. (A) Correlation between the proportion of HIV-1-specific interferon-γ secreting CD8+ T cells with effector phenotype and the corresponding epitope-specific CD8+ T-cell-mediated cytotoxic activity. Dashed lines represent the 95% confidence intervals of the regression line. (B) Epitope-specific cytotoxic activity of HIV-1-specific CD8+ T cells stratified according to their maturation phenotype. HIV-1-specific CD8+ T-cell populations with more than 20% of CCR7-/CD45RA+ cells were classified as terminally differentiated immune responses, whereas populations with less than 20% of CCR7-/CD45RA+ cells were regarded as preterminally differentiated immune responses.

No relationship between the epitope-specific cytotoxic activity of HIV-1-specific CD8+T cells and their maturation phenotype. (A) Correlation between the proportion of HIV-1-specific interferon-γ secreting CD8+ T cells with effector phenotype and the corresponding epitope-specific CD8+ T-cell-mediated cytotoxic activity. Dashed lines represent the 95% confidence intervals of the regression line. (B) Epitope-specific cytotoxic activity of HIV-1-specific CD8+ T cells stratified according to their maturation phenotype. HIV-1-specific CD8+ T-cell populations with more than 20% of CCR7-/CD45RA+ cells were classified as terminally differentiated immune responses, whereas populations with less than 20% of CCR7-/CD45RA+ cells were regarded as preterminally differentiated immune responses.

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