HOCl-LDL potentiates platelet aggregation according to its amount and extent of oxidation. (A) ADP (1 μM) and epinephrine (10 μM) top traces, ADP combined with HOCl-LDL at 0, 4, 10, 20, 40, and 100 μg/mL; bottom traces, epinephrine combined with HOCl-LDL at 0, 10, 20, 30, and 40 μg/mL. (B) Relative aggregatory effects of HOCl-LDL combined with 1 μM ADP (•) or 10 μM EPI (▴) (n = 3 donors). (C) Thrombin (i) alone (0.01 U/mL) or (ii) +HOCl-LDL at 20 μg/mL. (D) Effect of varying the extent of LDL oxidation: 1 μM ADP + 20 μg/mL LDL oxidized with HOCl for (i) 5, (ii) 10, (iii) 15, and (iv) 30 minutes (described in “Materials and methods”). MDA values are given as nmol/mg LDL protein.