Figure 4.
HOCl-LDL causes exposure of platelet P-selectin. Washed platelets were exposed to ADP (1 μM), HOCl-LDL (20 μg/mL or 133 μg/mL); (A) 1 μM ADP, 20 μg/mL HOCl-LDL, and their combination, as well as to thrombin (1U/mL); (B) 1 μM ADP, 133 μg/mL HOCl-LDL, and their combination, and to thrombin (1 U/mL); (C) 1 μM ADP and 20 μg/mL HOCl-LDL, with the latter combination in the presence of the PKC inhibitor bisindolylmaleimide at 3 μg/mL.