VEGF concentrations of patients with CML. (A) VEGF concentrations in bone marrow supernatants. The VEGF-A concentration of conditioned media was determined by ELISA and values are shown. Normal bone marrow obtained from 4 patients served as a control. Bone marrow specimens from 8 adult patients with newly diagnosed untreated CML were studied. (B) VEGF concentrations in plasma samples. Plasma samples from 14 patients with CML at diagnosis, 9 patients treated with imatinib and in complete cytogenetic response, and 10 healthy control individuals were analyzed by ELISA. Comparison between groups was performed and is represented by square brackets. Statistically significant comparisons are indicated by an asterisk (^*), P < .05. Horizontal bars and numbers represent median VEGF.