Increased levels of CXCL12 in the plasma of αM^–/– mice after fucoidan mobilization. αM^+/+ and αM^–/– mice were treated with 2 doses of PBS (□) or fucoidan (50 mg/kg; ▪). BM extracellular fluid (A) and plasma (B) were harvested for analysis of CXCL12 content by ELISA. Shown is the mean ± SEM concentration of CXCL12 from 3 independent experiments. *P < .01; **P < .0001; #P = .02 compared with PBS; ¥P = .04. n = 6-12 mice.