Effect of hypoxia-reoxygenation (H/R) on TF expression. Data are expressed as for Figure 3. H/R does not increase TF expression in the normal (Nor) mouse, but it converts the mild sickle mouse (NY1DD) to the severe, BERK-like TF-positive phenotype. Statistical significance: P < .001 for posthypoxia NY1DD (n = 9) versus prehypoxia NY1DD (n = 10); and P = ns for posthypoxia NY1DD (n = 9) versus BERK (n = 5); and P = ns for posthypoxia Nor (n = 11) versus prehypoxia Nor (n = 9).