Figure 1.
Correlation of transcriptional cofactor interaction domains and dimerization/oligomerization motifs in leukemia-associated fusion proteins. Chimeric oncoproteins are illustrated schematically with fusion partner moieties indicated in pink. X indicates that diverse proteins have been identified as fusion partners. Downward gray arrows indicate sites of dimerization/oligomerization. Upward black arrows indicate sites of transcriptional cofactor interaction. For dimerization-dependent MLL chimeras, the question mark indicates that the site of cofactor recruitment has not been determined.