Protocol used to assess survival and hematopoietic recovery. Water or perindopril (10, 30, or 90 mg/kg) was administered (↑) subcutaneously twice a day for 4 days beginning 48 hours before exposure to irradiation (gray arrow; single dose of either 7 Gy [nonlethal regimen] or 8.3, 8.7, or 9.1 Gy [lethal regimen]). (A) Peripheral blood (↓) and bone marrow (⊗) samples were collected every 2 or 3 days. Schematic representation of the experiments used to evaluate the short-term repopulating ability of bone marrow cells after reconstitution by survival and hematopoietic recovery (B). On day 46, bone marrow from 3 mice per group was grafted into 10 lethally irradiated mice.