Figure 5.
Effect of oral L1 administration: correlations between basal LPI, Tfsaturation, serum ferritin, and red blood cell membrane (RBCM) iron levels. The figure depicts results obtained either monthly or bimonthly with patients treated with L1 showing actual values of percent Tf saturation versus those of LPI (μM) (A) or those of percent Tf saturation versus those of SF (nanograms per milliliter) (B) and mean ± SEM values for LPI (μM) versus the respective mean ± SEM values of either SF (nanograms per milliliter) (C) or RBCM (nanomoles per milligram of protein) (D). The broken lines denote, for panels A and B, the value of 85 for percent Tf saturation; for panel A, 0.4 for LPI, and for panel B, 450 for SF. The correlations (corresponding mean ± SEM values plotted against each other) analyzed by the best linear fits yielded the following. (A) For LPI and RBCM iron (top): slope, 9 ± 1; intercept, –9 ± 3, r = 0.74; and (B) for LPI and SF (middle): slope, 660 ± 204; intercept, –100 ± 120, r = 0.78.