Poor inflammatory responses in vivo in XID mice. (A) Induction of EAE in WT or XID mice by immunization with spinal cord homogenate. Clinical scores are shown (mean ± SE) at the indicated time points. (B) Induction of colitis in WT or XID mice by administration of DSS in drinking water. The extent of weight change with reference to starting weight is shown at day 9 of treatment in WT and XID mice (mean ± SE). (C) Induction of footpad edema in WT or XID mice by administration of carrageenan. The increase in footpad thickness is shown (mean ± SE) over time.