EphrinB2 enhances angiogenesis and expression of syndecan-1 in the murine wound healing model. Collagen sponges containing either 2 μg preclustered ephrinB2 or 0.2 μg VEGF or clustering Ab alone (control) were implanted subcutaneously in mice for 7 days (n = 5 for each group). The collagen sponges with surrounding tissue were excised and embedded in paraffin and then processed for immunostaining of CD31 and syndecan-1. The positive reaction appeared red from peroxidase-AEC. eB2 indicates ephrinB2; cont, control. Original magnification × 100. Scale bar equals 75 μm.