Consumptive coagulopathy 4.5 hours after administration of LPS and l-NAME in bone marrow–reconstituted mice. Data from unmanipulated Hir-Tg and TFPI-Tg mice are also presented in Figure 4. All data are derived from 3 to 6 mice per group (error bars = SEM). §Clauss fibrinogen assay was stopped after 20 minutes (5% or less normal mouse plasma fibrinogen) if no clot was observed; therefore, this value is minimum fibrinogen value detectable by this assay. Comparing the BM-reconstituted mice. *P = .007, †P < .0001, #P = .0015.