Figure 1.
Figure 1. Spectrum of AML1 mutations. The horizontal line at the top represents the AML1b transcript. Horizontal light gray bars below represent the AML1 protein indicating the runt homology (RHD) and transactivation domains (TADs). The amino acid numbers are shown above the bars. The black vertical lines indicate the relative positions of the 22 AML1 mutations grouped as 9 missense mutations, 3 nonsense mutations, and 10 frameshift mutations. Dark gray bars represent the incorrect amino acids after the frameshifts. Patient numbers, mutated exons, and nucleotide substitutions are shown to the left, whereas the predicted protein changes are shown to the right. The nucleotide numbers are relative to the start codon ATG defined as +1ofthe AML1b transcript (blast accession no.: L34598). Ins denotes insertion; del, deletion; fs, frameshift; and ter, termination.

Spectrum ofAML1mutations. The horizontal line at the top represents the AML1b transcript. Horizontal light gray bars below represent the AML1 protein indicating the runt homology (RHD) and transactivation domains (TADs). The amino acid numbers are shown above the bars. The black vertical lines indicate the relative positions of the 22 AML1 mutations grouped as 9 missense mutations, 3 nonsense mutations, and 10 frameshift mutations. Dark gray bars represent the incorrect amino acids after the frameshifts. Patient numbers, mutated exons, and nucleotide substitutions are shown to the left, whereas the predicted protein changes are shown to the right. The nucleotide numbers are relative to the start codon ATG defined as +1ofthe AML1b transcript (blast accession no.: L34598). Ins denotes insertion; del, deletion; fs, frameshift; and ter, termination.

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