Rate of de novo purine synthesis (DNPS) in ALL cells of different genetic and lineage subtypes. The rate of de novo purine synthesis (DNPS) (femtomoles per nanomole per hour) is shown on a log scale for hyperdiploid B-lineage ALL (BHD, n = 26), ALL with the E2A-PBX translocation (E2A-PBX, n = 7), ALL with TEL-AML1 translocation (TEL-AML, n = 30), no defined genetic or chromosomal abnormalities (B-other, n = 33), and T-lineage (T, n = 17). The horizontal lines indicate the median for each subgroup; the top and bottom of each box depict the 25th and 75th percentile value. The dashed lines depict 1.5 times the interquartile range. The outlier values are shown with diamond symbols. The P values were determined by the Wilcoxon rank sum test adjusted for multiple testing.