Cartoon depicting portions of the signaling network linking αIIbβ3 to actin polymerization and reorganization. The insert provides a key to some of the modules or domains within the proteins that mediate or regulate protein functions and/or interactions. Domain abbreviations: CH, calponin homology; P-Tyr, phosphotyrosine; PTB, phosphotyrosine binding; PH, pleckstrin homology; WH, WASP homology; and VH, verprolin homology. WIP indicates WASP-interacting protein; PLCγ, phospholipase Cγ. The figure is offered solely to provide a visual context for the discussion in the text of early phases of outside-in signaling. No attempt is made to show all proteins involved or all interactions of a given protein, and important signaling cross-talk between αIIbβ3 and other platelet receptors is not depicted.9 See Bearer et al,109 Hartwig et al,111 and Calderwood et al124 for reviews of integrin-dependent actin dynamics and organization in platelets.
