Tissue invasion of rhesus LCV-positive cells in Mm321-98. (A) Hematoxylin and eosin–stained section of a lymph node biopsy performed on day 36 after intravenous inoculation of autologous rhesus LCV-immortalized B cells. Original magnification × 100. (B) EBERs in situ hybridization (original magnification × 200) and (C) EBNA-2 immunohistochemistry on sections of the same lymph node biopsy (original magnification × 200). (D) Hematoxylin and eosin–stained section from the spleen obtained at necropsy on day 57 (original magnification × 100). (E) EBERs in situ hybridization (original magnification × 20) and (F) EBNA-2 immunohistochemistry on sections from the spleen (original magnification × 100).