Figure 1.
Figure 1. Amidolytic and anticoagulant activity of rwt APC and APC variants. (A) Amidolytic activity of rwt APC and APC variants against the small chromogenic substrate, S-2366. (B) Anticoagulant activity of rwt APC and APC variants determined using activated partial thromboplastin time (APTT) assays. Each point represents the mean ± SEM from at least 3 independent experiments. □ indicates rwt APC; ○, 229/230-APC; ⋄, 3K3A-APC; and ▪, S360A-APC.

Amidolytic and anticoagulant activity of rwt APC and APC variants. (A) Amidolytic activity of rwt APC and APC variants against the small chromogenic substrate, S-2366. (B) Anticoagulant activity of rwt APC and APC variants determined using activated partial thromboplastin time (APTT) assays. Each point represents the mean ± SEM from at least 3 independent experiments. □ indicates rwt APC; ○, 229/230-APC; ⋄, 3K3A-APC; and ▪, S360A-APC.

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