Reactivities and cofactor dependencies of CIC7, CIC15, and GL. See “Results.” (A) Reactivity with CL, PS, and PC during ELISA assays in presence of FCS, CIC15 (▪), CIC7 (•), GL (□), and normal human IgG (▴). (B) Cofactor dependency of CIC15 and GL anti-CL reactivity: Results are expressed as percentages of the increase of binding on CL in presence of FCS, prothrombin (Pt), protein S (S), protein C (C), annexin A5 (A5), β 2-glycoprotein I (GpI), and BSA compared with the binding to CL without the cofactors. (C) Binding of CIC15 on delipidized recombinant annexin A5 (⋄) or complexes of CL-annexin A5 (♦).