Figure 2.
BM oligoclonal T-cell expansion in mice with BM failure. BM cells from control and BM failure B6D2F1 mice were analyzed for the expression of Vβ TCR repertoire. Proportions of each specific Vβ TCR repertoire relative to the sum of all 15 Vβ TCR repertoires (Vβ 2, 3, 4, 5.1/5.2, 6, 7, 8.1/8.2, 8.3, 9, 10, 11, 12, 13, 14, 17a) on BM CD8+ T cells were compared between BM failure mice and control mice. Data shown are fold increases in each Vβ TCR repertoire in BM failure mice from 3 independent experiments.