Response of DRS-1–specific T cells to APCs with DRB1*1501 expressing the DRS-1 gene and immature myeloid cells. (A) 3H-thymidine incorporation of DRS-1–specific T cells to DRS-1–transduced 1501-L cells and 0101-L cells, as well as nontransduced 1501-L cells. Values represent mean + SD of triplicate cultures from 4 different experiments. (B) Cytotoxicity of DRS-1–specific T cells against DRS-1–transduced 1501-L cells and 0101-L cells, as well as nontransduced 1501-L cells. L-cell transfectants were incubated with differing numbers of DRS-1–specific T cells in a 4-hour cytotoxicity assay. Values represent mean ± SD of duplicate cultures from 3 different experiments. Asterisks in Figure 5A-B indicate values significantly different from nontransduced 1501-L cells or transduced 0101-L cells (*P < .05, **P < .001). E/T indicates effector-target ratio.
