Atherosclerotic lesions in Ldlr^-/- mice reconstituted with BM cells from CD1d^-/- or WT mice. (A) Representative CD1d expression pattern on thymocytes from [WT→Ldlr^-/-] and [CD1d^-/-→Ldlr^-/-] mice. Red lines and filled histograms indicate CD1d staining and isotype control, respectively. (B) Thy1.1 and Thy1.2 expression on thymocytes from [WT→Ldlr^-/-] and [CD1d^-/-→Ldlr^-/-] chimeras. Representative results of Thy1.1 and Thy1.2 stainings are shown in the right panels with their respective isotype controls (left panels). (C) Representative histologic sections of [WT→Ldlr^-/-] and [CD1d^-/-→Ldlr^-/-] mice stained with oil red O (original magnification, × 40). Arrowheads represent oil red O-positive lesions. (D) Lesion area in [WT→Ldlr^-/-] and [CD1d^-/-→Ldlr^-/-] mice. Each symbol represents the lesion area of an individual mouse. Horizontal bars and numbers represent the mean of all mice within each group. ^**P < .01 (E) Representative immunohistochemical section of [WT→Ldlr^-/-] and [CD1d^-/-→Ldlr^-/-] mice. Sections were stained with anti-MOMA-2, anti-CD3, and anti-IFN-γ mAb (original magnification, × 200). Arrowheads represent respective mAb-positive cells. (F) Numbers of CD3⁺ cells per cross-section of lesion area. ^**P < .01.