Serum BLyS levels in NHL are elevated and correlate with overall patient survival. (A) Serum BLyS levels were analyzed by ELISA in specimens obtained from healthy individuals (n = 6) or patients with indolent (n = 11) and DLC lymphoma (n = 56). Serum concentrations in patients were compared to those in healthy controls. The solid line represents the median value for the group. (B) Kaplan-Meier analysis was done to compare the survival of patients with low BLyS levels (< 40 ng/mL) at diagnosis to those with high levels (> 40 ng/mL). Patients with high levels had a significantly worse outcome (P = .05).