Figure 4.
Role of α4β7 in progenitor homing to bone marrow. Lethally irradiated wild-type (WT) or E-selectin–deficient mice (E–/–) were injected with antibody-treated wild-type donor BM cells. CFU-Cs were determined from the recipient BM and spleen that were harvested 3 hours after injection. (A) Transplantation of donor cells treated with rat IgG, anti-α4 integrins (PS/2), or anti-α4β7 (DATK32) into WT recipient mice. n = 8-12 mice per group for BM and n = 6-8 for spleen. (B) Transplantation of antibody-treated donor cells into E–/– recipient mice. n = 6 per group. *P < .05; **P < .01 compared with rat IgG control group. Data are presented as means ± SEM.
