P-selectin deficiency plays a major role in acceleration of CML-like leukemia induced by BCR/ABL (A) Kaplan-Meier survival curve for recipients of marrow transduced by BCR/ABL. Recipient mice received a cell dose of 2 × 10⁵ cells/mouse. Mice lacking P-selectin only and lacking both P-selectin and ICAM1 had a significant acceleration in the development of CML-like leukemia compared to both control (WT) mice and mice lacking ICAM1 only (P = .001). ICAM1-deficient mice also had a slight but statistically significant acceleration of CML development compared to control mice (P = .000). There were no significant differences (mean values ± SD) in white blood cell counts (B) and spleen weights (C) among the 4 transplant groups.