Figure 6.
Lack of P-selectin and ICAM1 does not accelerate the development of BCR/ABL-induced B-ALL. (A) Kaplan-Meier survival curve for recipients of marrow transduced by BCR/ABL. Recipient mice received a cell dose of 1 × 106 cells/mouse. There was no significant difference in survival between wild-type (WT) recipients of transduced WT marrow and P-selectin/ICAM1-deficient recipients of transduced P-selectin/ICAM1-deficient marrow (P = .673). (B) Mean spleen weight (mean values ± SD) of leukemic mice (measured at the time of morbidity or death). There was no significant difference in spleen weight between the 2 transplant groups (P = .474).