A bisphosphonate inhibited OC-mediated MM cell growth on dentine slices. OCs were purified from rabbit bone cells and plated out on dentine slices in 96-well culture plates. Subsequently, human myeloma OPC cells (2 × 10⁴/mL) and minodronate at 0.1 μM were added to the indicated wells in quadruplicate. After 4 days, the number of resorption pits on dentine slices was counted (A). Isolated OCs were cocultured with OPC cells on dentine slices in quadruplicate, minodronate was added at 0.1 μM into the indicated wells, culture supernatants were harvested at day 4, and IgG concentrations were measured by ELISA (B). Data are expressed as means ± SD. *Significantly different by one-way ANOVA with Scheffe post hoc tests, P < .05.