Different phenotypes of HSC have different characteristics regarding hepatocyte production. Low and high magnification of sections of livers from secondary sheep that received transplanted human cells from (A) CD34⁺Lin^–CD38^–, (B) CD34^–CD38^–Lin^–, or (C) CD34⁺CD133⁺ Lin^– primary recipients (high magnification Ai, Bii, C). Liver sections were stained with an antibody antihuman hepatocyte (clone OCH1E5), as described in “Materials and methods.” Animals that received transplanted CD38^– populations displayed multiple hepatocytic foci throughout the hepatic parenchyma at levels similar to those generated in the primary recipients (A-B). Few hepatocytes were found in the liver sections of CD34⁺CD133⁺Lin^– secondary recipients (C).