Hierarchic clustering FLT3-MU samples supervised by SAM-derived RUNX3 cluster (12 genes) and ATRX gene. SAM-derived RUNX3 cluster identified a significantly different gene expression pattern that correlated with clinical outcome. The ATRX helicase had an inverse correlation with expression level of RUNX3. Cases with poor outcome had elevated RUNX3 expression and low expression of ATRX.