Dose-response curves for G-CSF effects. Quantitative relationship between the circulating G-CSF level (expressed as fraction of the G-CSF level in the normal steady state) and the 3 modes of G-CSF action. Curve A_PGP describes the number of additional mitoses at the stage of myeloblasts, promyelocytes, and myelocytes. T_MGP describes the transit time in the postmitotic compartment, and R_MGP describes the fraction of cells released from bone marrow into peripheral circulation.