Figure 2. Alignment of amino acid sequences in groups with restricted HCDR3s. Alignment of amino acid sequences from the VH gene and VL gene rearrangements in the 3 groups with highly restricted HCDR3s (the VH3-21 alignment has been published elsewhere18; A) and the 3 groups with moderate HCDR3 restriction (B). The VH gene rearrangements sequences are shown to the left and the VL sequences to the right. A dot indicates homology with the top sequence. The CDR1, CDR2, and CDR3 are indicated. The D gene segment and the start of the JH/JL genes are underlined. In CLL27, the third amino acid in the HCDR3 is underlined, as it is part of the D3-16 gene. ND indicates that the rearrangement was not determined; and *, position with allelic variants.
Figure 2.

Alignment of amino acid sequences in groups with restricted HCDR3s. Alignment of amino acid sequences from the VH gene and VL gene rearrangements in the 3 groups with highly restricted HCDR3s (the VH3-21 alignment has been published elsewhere18 ; A) and the 3 groups with moderate HCDR3 restriction (B). The VH gene rearrangements sequences are shown to the left and the VL sequences to the right. A dot indicates homology with the top sequence. The CDR1, CDR2, and CDR3 are indicated. The D gene segment and the start of the JH/JL genes are underlined. In CLL27, the third amino acid in the HCDR3 is underlined, as it is part of the D3-16 gene. ND indicates that the rearrangement was not determined; and *, position with allelic variants.

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