Alignment of HCDR3 amino acid sequences obtained from 20 V_H1-69 using rearrangements. The V_L gene usage in each case is indicated to the right. A dot indicates homology with the top sequence. The 4 V_H1-69/D3-16/J_H3 and the 2 V_H1-69/D3-3/J_H6 rearrangements are aligned to the top sequence in respective group, whereas the amino acid sequences from the remaining V_H 1-69⁺ sequences are presented without alignment.