Organization of genes in the human and mouse GATA1 loci and sequence comparison between the mouse and human GATA1 loci. (A-B) Mouse (A) and human (B) GATA1 loci are illustrated. Above each locus, the scale is in kilobases, and coordinate 0 is at the mRNA cap site of GATA1 transcribed from the IE promoter. Genes are shown as dark boxes. Genes above the line are transcribed in the same direction as GATA1; PCSK1N is transcribed in the opposite direction and drawn below the locus. (C) Plot of sequence comparison of the mouse (reference sequence) and human GATA1 loci from SUV39H1 to PCSK1N. The y-axis is the percent sequence identity over a moving 100–base pair window. Different points along the Gata1 loci are represented on the x-axis. Different features in Gata1 loci are shown: genes (black lines), exons within genes (blue boxes), and regulatory elements (pink boxes). (D) Distribution of GATA sites (WGATAR) through the mGata1 locus. The coordinates are in kilobases with respect to the GATA1 IE promoter transcriptional start site. The genes are shown as black boxes, the positions of known mGATA1 cis-elements are marked by gray arrows, and the distribution of GATA sites is shown as black vertical lines below the rest of the panel.