Examples of previously unidentified DNase HSs in the h GATA1 locus. (A) The hGATA1 locus, positions of constitutive (black arrows), hematopoietic (gray arrows), and eosinophil-specific (open arrows) DNase I HSs and the region of chromatin (gray bar) that was systematically surveyed throughout for DNase I HSs are depicted as in Figures 1B and 2A. (B-H) Maps of the relevant portions of the genomic hGATA1 locus, together with examples of DNase I HSs, are shown. The organization of these parts of the figure is the same as in Figure 2B-G. Abbreviations for cells used are as follows: I^o Ery, primary erythroid cells; K562, myeloid/erythroleukemia cell line; I^o eos, primary eosinophils; AML, eosinophil myelocyte cell line; and Hela, fibroblast cell line. Additional restriction enzymes used are Sc, ScaI; D, DraI; and HII, HindII.