Figure 3.
![Figure 3. Inhibition of choline uptake by novel antimalarials. (A) Concentration-dependent inhibition by T16 of [3H]-choline (15 μM) uptake into isolated P falciparum parasites over 10 minutes at 22°C. Data are mean ± SD for duplicate observations from 3 individual experiments. (B) Lineweaver-Burke (double reciprocal) plot of choline uptake as a function of external choline concentration into isolated P falciparum parasites over 10 minutes at 22°C. Data are presented for choline alone (○) or choline in the presence of 10 μM pentamidine (•). Data are mean ± SD for duplicate observations from 3 individual experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/104/10/10.1182_blood-2004-03-1084/6/zh80220469140003.jpeg?Expires=1735546726&Signature=AjQhOv7tTLhUwr7jquxmKv-~dwtWQJHOAecTzgvZXdCSRt4-R0lHDG~R~mF-GTEjYgndtQBa85y2wD9YnOuWL4Ule01vo3N6Ivp6Lyd4tYDJeJh1aV0ZkO5sM43GUb~7BXVv7uSdqyC63AJNAv3f2dZETIo69AifrmZ6XPhGreQUXoiQYOSkjaADXlv-9REsbQ7-P5ZKefSkGQwAh7~IyXg4bQtd~SnHs7FexaFVUMjt8RNhYQVaMemtq3HaMi2LAR1319c67InQ4RR~oIRBe6LJTDS~LDwHrNhzOHnLoxrAuV2J2OQxZP-htLFNi6gcsaiIdGSJW78nVA6NsrbZSA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Inhibition of choline uptake by novel antimalarials. (A) Concentration-dependent inhibition by T16 of [3H]-choline (15 μM) uptake into isolated P falciparum parasites over 10 minutes at 22°C. Data are mean ± SD for duplicate observations from 3 individual experiments. (B) Lineweaver-Burke (double reciprocal) plot of choline uptake as a function of external choline concentration into isolated P falciparum parasites over 10 minutes at 22°C. Data are presented for choline alone (○) or choline in the presence of 10 μM pentamidine (•). Data are mean ± SD for duplicate observations from 3 individual experiments.
