![Figure 1. The aPTTs, lepirudin plasma levels, and creatinine levels of patients with and without a major bleed. (A) The aPTT values of patients with a bleeding event versus patients without. On the left, the individual aPTT values at the time of bleeding are given. The left box plot summarizes all aPTTs in the patients who had a major bleeding event up to the time of bleeding: 25% (67.0 seconds) and 75% (79.0 seconds) quartiles and median (75.0 seconds), mean (+; 73.7 seconds), and minimum (50.0 seconds)/maximum (86.0 seconds). The right box plot summarizes all aPTTs in the patients without a bleed (P < .0001): 25% (47.0 seconds) and 75% (60.0 seconds) quartiles and median (52.9 seconds), mean (+; 53.0 seconds), and minimum (42.0 seconds)/maximum (69.0 seconds). The range of the gray area divides most of the patients in the 2 groups. (B) Lepirudin plasma levels of patients with bleeding event versus patients without. On the left, the individual values at the time of bleeding are given (n = 9). The left box plot summarizes all values in the patients with a bleed up to the time of bleeding: 25% (670.0 μg/L) and 75% (1422.0 μg/L) quartiles and median (1152.0 μg/L), mean (+; 1145.0 μg/L), and minimum (270.0 μg/L)/maximum (2048.0 μg/L). The right box plot summarizes all plasma levels in patients without a bleed (P < .0001): 25% (445.0 μg/L) and 75% (655.0 μg/L) quartiles and median (552.0 μg/L), mean (+; 555.1 μg/L), and minimum (15.6 μg/L)/maximum (1180.0 μg/L). The range of the gray area divides most of the patients in the 2 groups. (C) Serum creatinine levels of patients with bleeding event versus patients without. The left box plot summarizes all values in the patients with a bleed up to the time of bleeding: 25% (106.1 μmol/L [12.0 mg/L]) and 75% (132.6 μmol/L [15.0 mg/L]) quartiles and median (113.2 μmol/L [12.8 mg/L]), mean (+; 125.5 μmol/L [14.2 mg/L]), and minimum (70.7 μmol/L [8.0 mg/L])/maximum (303.2 μmol/L [34.3 mg/L]). The right box plot summarizes all creatinine levels in the patients without a bleed (P < 0.0001): 25% (61.9 μmol/L [7 mg/L]) and 75% (85.7 μmol/L [9.7 mg/L]) quartiles and median (70.7 μmol/L [8.0 mg/L]), mean (+; 77.8 μmol/L [8.8 mg/L]), and minimum (53.9 μmol/L [6.1 mg/L])/maximum (95.5 μmol/L [10.8 mg/L]). The range of the gray area divides most of the patients in the 2 groups.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/104/10/10.1182_blood-2004-02-0621/6/zh80220469200001.jpeg?Expires=1735835721&Signature=VCSxb4Dmss1F-1zSAmCEhx6ffui70pbcDKLZ4vAxBGx1383PCGqUg6VcAzfZT3q~abHUFeo9-YEcINNO-2CeDBUNCufrpE-ETjBUWmvInX~UGYx6JBjX3X~TmWiYbJ7rZOqtBTR3jClcHXcZQNdAg5j--JkvVn46gcbDvn5b9BX6dRIC6FgWW2Vh3wNfgLrSvbwP33T4CKzb8vmqgAdhNw25GeM5kJdA4a-CjOl4t7M39HFEt33GAtqeeaZadTh4XWLvE2-kfZJtKnEljkvcm~D3-WvCBuzDq77tn0pBRp3iB2RdHYAif31tz9XM-Af7~hTGpRizpa7S73GAw1RO2w__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The aPTTs, lepirudin plasma levels, and creatinine levels of patients with and without a major bleed. (A) The aPTT values of patients with a bleeding event versus patients without. On the left, the individual aPTT values at the time of bleeding are given. The left box plot summarizes all aPTTs in the patients who had a major bleeding event up to the time of bleeding: 25% (67.0 seconds) and 75% (79.0 seconds) quartiles and median (75.0 seconds), mean (+; 73.7 seconds), and minimum (50.0 seconds)/maximum (86.0 seconds). The right box plot summarizes all aPTTs in the patients without a bleed (P < .0001): 25% (47.0 seconds) and 75% (60.0 seconds) quartiles and median (52.9 seconds), mean (+; 53.0 seconds), and minimum (42.0 seconds)/maximum (69.0 seconds). The range of the gray area divides most of the patients in the 2 groups. (B) Lepirudin plasma levels of patients with bleeding event versus patients without. On the left, the individual values at the time of bleeding are given (n = 9). The left box plot summarizes all values in the patients with a bleed up to the time of bleeding: 25% (670.0 μg/L) and 75% (1422.0 μg/L) quartiles and median (1152.0 μg/L), mean (+; 1145.0 μg/L), and minimum (270.0 μg/L)/maximum (2048.0 μg/L). The right box plot summarizes all plasma levels in patients without a bleed (P < .0001): 25% (445.0 μg/L) and 75% (655.0 μg/L) quartiles and median (552.0 μg/L), mean (+; 555.1 μg/L), and minimum (15.6 μg/L)/maximum (1180.0 μg/L). The range of the gray area divides most of the patients in the 2 groups. (C) Serum creatinine levels of patients with bleeding event versus patients without. The left box plot summarizes all values in the patients with a bleed up to the time of bleeding: 25% (106.1 μmol/L [12.0 mg/L]) and 75% (132.6 μmol/L [15.0 mg/L]) quartiles and median (113.2 μmol/L [12.8 mg/L]), mean (+; 125.5 μmol/L [14.2 mg/L]), and minimum (70.7 μmol/L [8.0 mg/L])/maximum (303.2 μmol/L [34.3 mg/L]). The right box plot summarizes all creatinine levels in the patients without a bleed (P < 0.0001): 25% (61.9 μmol/L [7 mg/L]) and 75% (85.7 μmol/L [9.7 mg/L]) quartiles and median (70.7 μmol/L [8.0 mg/L]), mean (+; 77.8 μmol/L [8.8 mg/L]), and minimum (53.9 μmol/L [6.1 mg/L])/maximum (95.5 μmol/L [10.8 mg/L]). The range of the gray area divides most of the patients in the 2 groups.
