Figure 4.
Figure 4. Reduction of TH1 cytokines, but not TH2 cytokines, chemokines, and adhesion molecules by Bcl-2 overexpression during acute rejection in allografts. At 8 days after transplantation, the cardiac allografts were harvested, and lysates from the cardiac allografts were prepared as described in “Materials and methods.” (A) Production of TNF-α, (B) IFN-γ, (C) MCP-1/CCL2, (D) IP-10/CXCL10, (E) MIG/CXCL9, (F) IL-4, (G) IL-10, (H) ICAM-1, and (I) VCAM-1 in heart lysates was measured by ELISA. Filled columns show the data from WT heart grafts (n = 6), and open columns show data from the Bcl-2 Tg heart grafts (n = 6). Mean ± SD values are shown. NS indicates not significant.

Reduction of TH1 cytokines, but not TH2 cytokines, chemokines, and adhesion molecules by Bcl-2 overexpression during acute rejection in allografts. At 8 days after transplantation, the cardiac allografts were harvested, and lysates from the cardiac allografts were prepared as described in “Materials and methods.” (A) Production of TNF-α, (B) IFN-γ, (C) MCP-1/CCL2, (D) IP-10/CXCL10, (E) MIG/CXCL9, (F) IL-4, (G) IL-10, (H) ICAM-1, and (I) VCAM-1 in heart lysates was measured by ELISA. Filled columns show the data from WT heart grafts (n = 6), and open columns show data from the Bcl-2 Tg heart grafts (n = 6). Mean ± SD values are shown. NS indicates not significant.

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