CpG-A stimulates production of significant levels of IFN-α from PBMCs of SS patients. PBMCs from SS patients (n = 12, ▪) and healthy volunteers (n = 6, ▦) were stimulated with 5 μg/mL of CpG-A, CpG-B, or control CpG ODN for 24 hours. Cytokine levels were measured in cell-free supernatants by ELISA. Data represent means (± SD) of tested individuals. ^**P < .001 compared with medium.