CpG-B up-regulates HLADR expression on CD123 plasmacytoid dendritic cells from SS patients. PBMCs from SS patients and healthy volunteers were stimulated with CpG ODN as described in Figure 2. After 24 hours of culture, cells were harvested and PBMCs from SS patients (n = 8, ▪) and healthy volunteers (n = 5, ▦) were excluded of all lineage-positive cells (Lin 1-FITC cocktail), whereas lineage-negative cells were analyzed for the co-expression of HLADR and CD123. Data represent means (± SD) of tested individuals and presented as MFI. ^***P < .0001 compared with medium or control CpG.